Key result
New-onset persistent left bundle branch block after TAVR was associated with an increased risk of hospitalization for heart failure (HR 1.34; 95% CI 1.01-1.76; P=0.04) over 5 years.
Why the study?
Long-term data on the relevance of new-onset persistent left bundle branch block after TAVR are sparse.
Does new-onset persistent left bundle branch block after TAVR increase the risk of adverse clinical outcomes compared to no or transient LBBB?
Cohort (n=551)
Does new-onset persistent left bundle branch block after TAVR increase the risk of adverse clinical outcomes compared to no or transient LBBB?
Hazard Ratio: 1.34 (95% CI 1.01–1.76)
p-value: p=0.04
New-onset persistent LBBB after TAVR is associated with an increased long-term risk of heart failure hospitalization and a decline in left ventricular ejection fraction.
Background Long‐term data on the relevance of new‐onset persistent left bundle branch block (pLBBB) after transcatheter aortic valve replacement (TAVR) are sparse. This study aimed to assess the impact of pLBBB that occurs after TAVR on mortality, hospitalisation for heart failure, new permanent pacemaker (PPM) implantation, and left ventricular ejection fraction (LV‐EF). Aims To investigate the impact of pLBBB on long‐term outcomes after TAVR. Methods After exclusion of patients with baseline conduction disorders, a pre‐existing PPM, valve‐in‐valve treatment, or in‐hospital mortality, a total of 551 patients were analysed. Patients were divided into two groups (pLBBB and no/transient LBBB) and followed over 5 years. Results A pLBBB occurred in 85 patients (15%). Patients with pLBBB had a significantly deeper valve implantation (4.0 ± 1.8 mm vs. 3.3 ± 1.8 mm, p < 0.01). pLBBB was associated with an increased risk for hospitalisation for heart failure (HRadjusted 1.34, 95% CI 1.01−1.76, p = 0.04), whereas all‐cause mortality was not elevated. The presence of pLBBB was linked to a significant decline in LV‐EF over the follow‐up period (58% ± 11% to 55% ± 12%, p = 0.03). There was a trend toward more new PPM implantation but no significant difference (HRadjusted 1.45, 95% CI 0.96−2.18, p = 0.07). A transient LBBB did not affect the studied outcomes. Conclusions During long‐term follow‐up, patients with a pLBBB were more often hospitalised for heart failure, and experienced a significant reduction in LV‐EF in comparison to patients with no or only transient LBBB.
No takes yet. Share an insight, caveat, or question.
Moccetti et al. (2025) conducted a cohort in Transcatheter Aortic Valve Replacement (TAVR) (n=551). New-onset persistent left bundle branch block (pLBBB) vs. No or transient LBBB was evaluated on Hospitalisation for heart failure (HR 1.34, 95% CI 1.01-1.76, p=0.04). New-onset persistent left bundle branch block after TAVR was associated with an increased risk of hospitalization for heart failure (HR 1.34; 95% CI 1.01-1.76; P=0.04) over 5 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: