Key result
Type II diabetes in ZDF rats increased end diastolic volume by 37% at 36 weeks (p<0.05) alongside progressive renal changes, without evidence that one pathology precedes the other.
Population
30 rats, divided into Lean Control and type II diabetic Zucker diabetic fatty rats.
Comparison
Observation of disease progression in the ZDF… vs Age-matched Lean Control (LC) rats.
Design
Preclinical
Follow-up
Up to 36 weeks of age (26 weeks from baseline)
Authors
Loading...
Concurrent cardiorenal changes in diabetic rats are hypothesis-generating; leaves open sequence of organ involvement in human type 2 diabetes.
p-value: p=<0.05
In the ZDF rat model of type II diabetes, cardiac and renal dysfunction develop concurrently rather than sequentially.
Baynes et al. (2009) studied Type II diabetes (n=30). Type II diabetes (ZDF model) vs. Lean Control (LC) rats was evaluated on LV structural/functional parameters and renal function (p=<0.05). Type II diabetes in ZDF rats increased end diastolic volume by 37% at 36 weeks (p<0.05) alongside progressive renal changes, without evidence that one pathology precedes the other.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: