Key result
The development of type 2 diabetes in Zucker diabetic fatty rats was associated with significantly higher functional recovery upon reperfusion after low-flow ischemia compared with controls.
In a rat model of type 2 diabetes, the transition to hyperglycemia was surprisingly associated with improved functional recovery after ischemia, despite progressive contractile abnormalities.
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Does not support changing ischemic management in diabetes; leaves open whether hyperglycemia duration confers protection in human type 2 diabetes.
Wang et al. (2004) studied Type 2 diabetes and myocardial ischemia. Type 2 diabetes (Zucker diabetic fatty rats) vs. Age-matched lean Control rats was evaluated on Functional recovery upon reperfusion after low-flow ischemia. The development of type 2 diabetes in Zucker diabetic fatty rats was associated with significantly higher functional recovery upon reperfusion after low-flow ischemia compared with controls.
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