Influence of diabetes mellitus duration on the efficacy of ischemic preconditioning in a Zucker diabetic fatty rat model
Key result
Ischemic preconditioning significantly reduced myocardial infarct size in both non-diabetic and type 2 diabetic rats irrespective of the duration of diabetes (ANOVA P<0.0001).
Why the study?
Does ischemic preconditioning reduce infarct size in a rat model of pre-, early, and late-stage type 2 diabetes mellitus?
Population
Male Zucker diabetic fatty rats (homozygote) at ages 6-, 12- and 24-weeks of age and their age-matched…
Comparison
Ischemic preconditioning (IPC) stimulus vs Control (no IPC)
Design
Preclinical, randomised
Authors
Discussion
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Implication
IPC efficacy preserved across T2DM durations despite varying IR sensitivity; leaves open translation to human preconditioning strategies.
Structured PICO
Does ischemic preconditioning reduce infarct size in a rat model of pre-, early, and late-stage type 2 diabetes mellitus?
P
Population
112 male Zucker diabetic fatty rats and non-diabetic controls at 6, 12, and 24 weeks of age subjected to ischemia-reperfusion injury in an isolated heart model.
I
Intervention
Ischemic preconditioning (IPC) stimulus
C
Comparator
Control (no IPC)
O
Outcome
Infarct size and myocardial glucose oxidation ratesurrogate
Main Result
p-value: p=<0.0001
Ischemic preconditioning preserves its cardioprotective effect against ischemia-reperfusion injury regardless of the duration of type 2 diabetes in a rat model.
Limitations
- Did not measure respiratory chain enzymes and western blotting of ischemia regulators
- Artificial intervention of IPC may differ from naturally occurring IPC (preinfarction angina)
- Isolated heart model with glucose as the sole substrate
- Animal model develops T2DM very rapidly compared to humans
Cite This Study
Hjortbak et al. (2018) studied Type 2 Diabetes Mellitus and Myocardial Ischemia Reperfusion Injury (n=112). Ischemic preconditioning vs. No ischemic preconditioning (control) was evaluated on Infarct size (p=<0.0001). Ischemic preconditioning significantly reduced myocardial infarct size in both non-diabetic and type 2 diabetic rats irrespective of the duration of diabetes (ANOVA P<0.0001).