Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation
Why the study?
Does the progression of type 2 diabetes alter myocardial ischemia-reperfusion injury and glucose metabolism in Zucker diabetic fatty rats?
Population
6, 12 and 24 weeks old male Zucker diabetic fatty rats and their age-matched heterozygote controls
Comparison
40 min ischemia followed by 120 min reperfusion vs Age-matched heterozygote controls
Design
Preclinical
Follow-up
120 min reperfusion
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for time-dependent effects of diabetes on myocardial ischemia-reperfusion injury in rats; human studies needed before clinical translation.
Structured PICO
Does the progression of type 2 diabetes alter myocardial ischemia-reperfusion injury and glucose metabolism in Zucker diabetic fatty rats?
P
Population
6 (prediabetic), 12 (onset of T2DM) and 24 (late T2DM) weeks old male Zucker diabetic fatty rats (ZDF) and their age-matched heterozygote controls
I
Intervention
40 min ischemia followed by 120 min reperfusion
C
Comparator
Age-matched heterozygote controls
O
Outcome
Ischemia-reperfusion (IR) injury assessed by TTC-stainingsurrogate
The onset of type 2 diabetes in rats is associated with protection against ischemia-reperfusion injury due to altered glucose oxidation, whereas late diabetes exacerbates injury.
Cite This Study
Povlsen et al. (2013) studied this question.