Key result
A diagnosis of cancer was associated with an increased risk of developing new coronary artery calcium in both women (RR 1.32; P=0.04) and men (RR 1.29; P=0.01).
Why the study?
Does a diagnosis of cancer increase the development of coronary artery calcification in individuals initially free of cardiovascular disease and cancer?
Cohort (n=3,122)
Does a diagnosis of cancer increase the development of coronary artery calcification in individuals initially free of cardiovascular disease and cancer?
Effect estimate: RR 1.32 (women) and RR 1.29 (men)
p-value: p=0.04 (women), 0.01 (men)
A diagnosis of cancer is associated with the development of new coronary artery calcification, highlighting a potential mechanism for the increased risk of ischemic heart disease in oncology patients.
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Suggests elevated atherosclerotic risk in cancer survivors; hypothesis-generating and should not yet change practice.
Whitlock et al. (2015) conducted a cohort in Free of cardiovascular disease and cancer (n=3,122). Cancer diagnosis vs. No cancer was evaluated on Incidence of new CAC (baseline Agatston score of zero converting to detectable CAC) (RR 1.32 (women) and RR 1.29 (men), p=0.04 (women), 0.01 (men)). A diagnosis of cancer was associated with an increased risk of developing new coronary artery calcium in both women (RR 1.32; P=0.04) and men (RR 1.29; P=0.01).
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