Key result
Valve-preserving aortic root reimplantation combined with total aortic arch replacement was as safe as limited arch repair, with 0% operative mortality or paraplegia in both groups.
Why the study?
Patients with thoracic aortic disease often present with multisegment pathology, requiring evaluation of outcomes and patient selection for valve-preserving aortic root reimplantation combined with arch procedures.
Is valve-preserving aortic root reimplantation combined with total aortic arch replacement as safe and feasible as limited arch repair in patients with thoracic aortic disease?
Cohort (n=98)
Is valve-preserving aortic root reimplantation combined with total aortic arch replacement as safe and feasible as limited arch repair in patients with thoracic aortic disease?
Absolute Event Rate: 0% vs 0%
Single-stage complete proximal aortic repair including VPARR with total arch replacement is safe and facilitates further downstream interventions in patients with diffuse aortic pathology.
VPARR with arch repair appears feasible in selected multisegment disease; leaves open prospective validation of selection and durability.
Objective: Patients with thoracic aortic disease commonly present with concomitant multisegment pathology. We describe the patient population, analyze outcomes, and define the patient selection strategy for valve-preserving aortic root reimplantation (VPARR) combined with the arch procedure. Methods: From 2008 to 2018, 98 patients underwent VPARR combined with the aortic arch procedure (hemi-arch, 50% [ n = 49, limited repair]; total arch, 50% [ n = 49, complete repair] including 39 with elephant trunk). Indications for surgery were aneurysmal disease (61%) and aortic dissection (39%). The median follow-up was 17 months (IQR, 8 to 60 months). Results: There were no operative deaths or paraplegia, and 5 patients underwent re-exploration for bleeding. During follow-up, 2 patients required aortic valve replacement for severe aortic insufficiency at 1 and 5 years, and 4 patients died. In the limited repair group, 1 patient underwent reintervention for aortic arch replacement, whereas 4 patients underwent planned intervention (1 endovascular and 3 open thoracoabdominal aortic repair). In the complete repair group, 23 patients underwent planned intervention (15 endovascular and 8 open thoracoabdominal repair). Conclusions: Single-stage, complete, proximal aortic repair including VPARR combined with total aortic arch replacement is as safe and feasible to perform as limited arch repair and facilitates further intervention in carefully selected patients with diffuse aortic pathology at centers of expertise.
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Othman et al. (2022) conducted a cohort in Thoracic aortic disease (n=98). Valve-preserving aortic root reimplantation (VPARR) combined with total aortic arch replacement vs. VPARR combined with hemi-arch (limited repair) was evaluated on Operative deaths or paraplegia. Valve-preserving aortic root reimplantation combined with total aortic arch replacement was as safe as limited arch repair, with 0% operative mortality or paraplegia in both groups.
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