January 1, 1991Nucleic Acids ResearchOpen Access

The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant

View Full Paper

Ask AI

Bookmark

Population

Mouse CpG-rich island HTF9 promoter model

Design

Preclinical

Authors

MSMaria Patrizia SommaInstitute of Molecular Biology and Pathology CPClaudio PisanoBiogem PLPatrizia LaviaInstitute of Molecular Biology and Pathology

Discussion

Member takes

Implication

Redundancy may characterize CpG-rich housekeeping promoters; leaves open validation in human cardiovascular models.

Structured PICO

Population

Mouse CpG-rich island HTF9 promoter model

Intervention

Gel shift assays and deletion analysis using a CAT reporter gene

Outcome

Promoter strength and basal level of transcriptionsurrogate

The study demonstrates that the mouse CpG island HTF9 promoter contains multiple functionally redundant protein-binding elements, which may be a general feature of housekeeping CpG-rich promoters.

Cite This Study

Somma et al. (1991) studied this question.

synapsesocial.com/papers/6a94f86f77bd7906860f2e76 https://doi.org/10.1093/nar/19.11.2817

View Full Paper

Ask AI

Bookmark

The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider