Key result
Administration of 50 mg recombinant tissue plasminogen activator over 30 minutes successfully resuscitated a patient with cardiac arrest due to acute pulmonary embolism, though complicated by bleeding.
Case Report (n=1)
Administration of 50 mg rt-PA over 30 minutes successfully resuscitated a patient with cardiac arrest due to pulmonary embolism, though it was complicated by significant bleeding.
Supports exploration of thrombolysis in PE arrest; remains hypothesis-generating pending controlled data.
Anticoagulant therapy is the mainstay in the management of venous thromboembolism. Nevertheless, the situation is entirely different in the patients with submassive or massive pulmonary embolism (PE) and cardiac arrest, and the diagnosis and therapy strategy for such conditions are lacking. This patient, who presented with a cardiac arrest event after varicose vein surgery, was diagnosed as acute pulmonary embolism. She survived after administration of 50 mg recombinant tissue plasminogen activator (rt-PA) for over half an hour, along with continued anticoagulant therapy. Unfortunately, gastrointestinal and cerebral hemorrhaging occurred during the process.
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Wu et al. (2012) conducted a case report in Cardiac arrest due to acute pulmonary embolism (n=1). Recombinant tissue plasminogen activator (rt-PA) was evaluated on Survival and return of spontaneous circulation. Administration of 50 mg recombinant tissue plasminogen activator over 30 minutes successfully resuscitated a patient with cardiac arrest due to acute pulmonary embolism, though complicated by bleeding.
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