Key result
Administration of systemic thrombolytic therapy (r-tPA) during cardiopulmonary resuscitation successfully achieved return of spontaneous circulation and complete recovery in a patient with massive pulmonary embolism.
Why the study?
Pulmonary embolism complicated by cardiac arrest is almost always fatal, but a more favorable outcome is possible with rapid identification and quick re-establishment of pulmonary circulation with specific therapy.
Does r-tPA administration during CPR improve survival in a patient with massive pulmonary embolism causing cardiac arrest?
Case Report (n=1)
Does r-tPA administration during CPR improve survival in a patient with massive pulmonary embolism causing cardiac arrest?
Rapid identification and administration of systemic thrombolytics during CPR can lead to successful resuscitation and complete recovery in patients with massive pulmonary embolism causing cardiac arrest.
Case of survival in PE arrest with rapid therapy; hypothesis-generating and should not yet change practice.
Pulmonary Embolism (PE), when complicated by cardiac arrest, is almost always fatal despite all resuscitative efforts. However, a more favorable is possible when PE is rapidly identified as the cause of cardiac arrest and pulmonary circulation is quickly re-established by specific therapy. A 54-year-old woman was brought to the Emergency Department (ED) by 112 emergency ambulance service with the complaint of shortness of breath that had started 2 hours ago. She developed cardiac arrest while being physical examined 2 minutes after admission, and Cardiopulmonary Resuscitation (CPR) was immediately begun. Massive PE was considered the most likely diagnosis in the light of her history, physical examined, and bedside ultrasonography findings; thus, recombinant tissue Plasminogen Activator (r-tPA) was administered during CPR. The second CPR attempt achieved return of spontaneous circulation within 5 minutes. She was treated at intensive care unit for 32 days and discharged from the hospital with complete recovery.
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Yılmaz et al. (2022) conducted a case report in Massive pulmonary embolism causing cardiac arrest (n=1). Recombinant tissue Plasminogen Activator (r-tPA) was evaluated on Return of spontaneous circulation and survival to discharge. Administration of systemic thrombolytic therapy (r-tPA) during cardiopulmonary resuscitation successfully achieved return of spontaneous circulation and complete recovery in a patient with massive pulmonary embolism.
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