Key result
Administration of transplacental propranolol (90 mg/day) successfully resolved fetal tachyarrhythmias and ascites.
Case Report (n=1)
Transplacental propranolol successfully treated fetal atrial tachycardia and associated ascites diagnosed via magnetocardiography and direct fetal electrocardiography.
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May inform fetal tachyarrhythmia management; hypothesis-generating case report requiring prospective validation.
At 26 weeks of gestation, fetal tachyarrhythmias (about 250 bpm) and ascites were detected by ultrasonography, and oral treatment with propranolol (30 mg/day) was commenced. Within 10 h, the fetal heart rate changed to approximately 85 bpm. The averaged fetal magnetocardiogram triggered by R peaks showed P wave and QRS complexes and an extra P wave. In addition, many extra nonconducted P-waves were detected in a fetal direct electrocardiogram. At 27 weeks of gestation, fetal tachycardia occurred again, and arrhythmia was diagnosed as the result of a blocked premature atrial contraction (PAC) with intermittent atrial tachycardia by fetal electrocardiogram. Administration of transplacental propranolol (90 mg/day) resolved the fetal tachyarrhythmias and ascites. Further studies are required to evaluate the efficacy and adverse effects of propranolol for fetal atrial tachycardia.
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Ishii et al. (2003) conducted a case report in Fetal atrial tachycardia (n=1). Propranolol was evaluated on Resolution of fetal tachyarrhythmias and ascites. Administration of transplacental propranolol (90 mg/day) successfully resolved fetal tachyarrhythmias and ascites.
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