What question did this study set out to answer?

Quantify and mathematically model post-fracture healing timeframes to directly compare the temporal progression of endochondral ossification between mice and humans.

July 10, 2025Journal of Bone and Joint SurgeryOpen Access

Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing

View Full Paper

Ask AI

Bookmark

Authors

YJYohan JangMethodist Hospital LLLuke A. LopasUniversity of North Carolina at Chapel Hill TMTodd O. McKinleyMethodist Hospital

Discussion

Member takes

Implication

Comparative radiographic analysis demonstrates distinct healing timelines in mice and humans, highlighting mathematical scaling factors to translate orthopaedic fracture research between species.

Key Points

Quantify and mathematically model post-fracture healing timeframes to directly compare the temporal progression of endochondral ossification between mice and humans.
Reviewed radiographs of 330 human femoral shaft fractures (OTA/AO 32A–C, aged 18–55 years) and 309 surgically induced midshaft femoral fractures in 3-month-old C57BL6/J mice, all treated with intramedullary fixation.
Scored radiographs via the Modified Radiographic Union Score for Tibia (mRUST) and modeled temporal progression using a 4-parameter log-logistic curve parameterized by final union score (Y∞), healing rate (k), and time to half-healing (X0.5).
Time to half-healing (X0.5) occurred significantly earlier in mice at 11.77 days (95% CI, 11.56 to 11.98) compared with 91 days (95% CI, 83 to 99) in humans (p < 0.05).
Healing rate (k) was significantly higher in mice at 4.54/log(days) (95% CI, 4.30 to 4.77) versus 1.37/log(days) (95% CI, 1.28 to 1.45) in humans, alongside a lower plateau score (Y∞ = 14.70 vs. 16.78; p < 0.05).

Cite This Study

Jang et al. (2025) studied this question.

synapsesocial.com/papers/6a94fe7b948c2c98a4f57cf4 https://doi.org/10.2106/jbjs.24.01304

View Full Paper

Ask AI

Bookmark

Implication

Comparative radiographic analysis demonstrates distinct healing timelines in mice and humans, highlighting mathematical scaling factors to translate orthopaedic fracture research between species.

Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing

Discussion

Member takes

Implication

Key Points

Cite This Study

Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider