Why the study?
Does CEA monitoring predict tumor recurrence in patients with colorectal cancer?
Population
770 patients with colorectal cancer enrolled in multi-institutional adjuvant G.I. therapy protocols.
Design
Cohort
Follow-up
21 months minimum
Authors
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Preoperative CEA >5 ng/ml may stratify recurrence risk; hypothesis-generating and should not yet change surveillance practice.
Does CEA monitoring predict tumor recurrence in patients with colorectal cancer?
Elevated and steadily rising postoperative CEA levels are strongly associated with tumor recurrence in colorectal cancer, though individual variability precludes using specific monthly increase rates as strict management guidelines.
Steele et al. (1982) studied this question.
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