Key result
Elevated postoperative CEA links to ~11 months shorter median survival and lower resectability of recurrence.
Why the study?
The usefulness of postoperative CEA levels in the surveillance of colorectal cancer patients after curative resection was evaluated.
Does postoperative CEA level predict recurrence, resectability, and survival in patients after curative resection for colorectal cancer?
Population
569 patients undergoing curative resection for colorectal cancer
Comparison
Non-elevated CEA (≤5 ng/ml) vs elevated CEA (>5 ng/ml)
Design
Cohort study with serial CEA measurements every 6 months starting 3 months post resection
Follow-up
Median 40 months
Authors
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Elevated postoperative CEA may flag higher-risk colorectal cancer patients for closer follow-up; leaves open whether routine monitoring improves resectability or survival in prospective trials.
Cohort (n=569)
Does postoperative CEA level predict recurrence, resectability, and survival in patients after curative resection for colorectal cancer?
Absolute Event Rate: 27% vs 38%
p-value: p=<0.05
Postoperative CEA monitoring is a significant predictor of recurrence and survival in colorectal cancer patients, and an elevated level should prompt earlier imaging.
Bhatti et al. (2015) conducted a cohort in Colorectal cancer (n=569). Elevated postoperative CEA (>5 ng/ml) vs. Non-elevated CEA (≤5 ng/ml) was evaluated on Survival following resection (p=<0.05). Elevated postoperative CEA (>5 ng/ml) was associated with significantly shorter median survival (27 vs 38 months; p<0.05) and lower resectability of recurrence in colorectal cancer patients.
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