The IAHA test is a highly sensitive method for titrating animal virus antigens and antibodies, outperforming the standard complement fixation test.
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It was confirmed that the immune adherence hemagglutination (IAHA) test might be useful for the measurement of antigens and antibodies of some animal viruses. A suitable procedure of IAHA for the titration of animal virus and corresponding antibody was determined. No positive reaction of IAHA could be seen with any kind of primate erythrocytes except for human erythrocytes, and the guinea pig complement was proved to be the only source of complement suited for the positive IAHA reaction of animal virus and antibody.Several kinds of animal viruses including herpes simplex virus, SV40, adeno- and enteroviruses were examined by the IAHA method for its practical application. It was substantiated that this new method was 10 to 100 times as sensitive as the usual complement fixation test as regards both viral antigen and antibody titers. A few demerits of IAHA technique were also discussed.
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May improve viral titration sensitivity in animal models; leaves open translation to human diagnostics.
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Ito et al. (1966) studied this question.
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