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The injection of male rats with 25 mg 9α-fluoroprednisolone/kg body weight caused a 29 % decrease in thymus RNA concentration 20 hours after injection. At this time, acid RNase activity had increased to more than twice control values. Alkaline RNase activity in whole thymus homogenates were increased 4 hours post injection. The removal of an alkaline RNase inhibitor from thymus homogenates greatly altered the response to steroid. Control values of alkaline RNase activity were 6 fold greater in homogenates from which the inhibitor had been removed. No effect of steroid on alkaline RNase activity was detected in homogenates from which the inhibitor was removed. DNase II activity was significantly elevated 2 hours post injection and reached a peak 2 hours later. No decrease in DNA concentration of thymus homogenates could be demonstrated.
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Wiernik et al. (1965) studied this question.
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