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A method is presented for the computer-assisted selection of the mode of development for the separation of ten phenolic components. The method is based on simulation of isocratic and gradient development. The different combinations of isocratic and gradient development in one (1D) and two (2D) dimensions are tested. The qualities of chromatograms are evaluated by application of criteria such as the distance function and multipeak criterion.
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Markowski et al. (1995) studied this question.
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