Maximal Dyspnea on Exertion During Cardiopulmonary Exercise Testing Is Related to Poor Prognosis and Echocardiography With Tissue Doppler Imaging in Heart Failure
Key result
Maximal dyspnea on exertion during cardiopulmonary exercise testing was significantly correlated with E/E' (r=0.49; P<0.001) and added independent prognostic value (P<0.001).
Why the study?
Is maximal dyspnea on exertion during cardiopulmonary exercise testing associated with disease severity and prognosis in heart failure patients?
Population
376 heart failure patients (a subgroup of 243 underwent echocardiography with tissue Doppler imaging)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Maximal dyspnea on exertion may reflect diastolic dysfunction severity and prognosis in HF; extends CPX variables but requires prospective validation.
Study Design
Type
Cohort (n=376)
Structured PICO
Is maximal dyspnea on exertion during cardiopulmonary exercise testing associated with disease severity and prognosis in heart failure patients?
P
Population
376 patients with heart failure who underwent cardiopulmonary exercise testing to evaluate dyspnea on exertion.
E
Exposure
Assessment of maximal dyspnea on exertion (DOE) during cardiopulmonary exercise testing (CPX)
O
Outcome
Prognosis (assessed via multivariate Cox regression) and correlation with echocardiographic E/E' ratio
Main Result
Effect estimate: r(s)=0.49 for E/E' correlation; residual chi-square 17.4 for prognosis
p-value: p=<.001
Maximal dyspnea on exertion during cardiopulmonary exercise testing reflects disease severity and provides independent prognostic value beyond established CPX variables in heart failure patients.
Cite This Study
Guazzi et al. (2009) conducted a cohort in Heart failure (n=376). Maximal dyspnea on exertion (DOE) was evaluated on Prognosis and correlation with E/E' ratio (r(s)=0.49 for E/E' correlation; residual chi-square 17.4 for prognosis, p=<.001). Maximal dyspnea on exertion during cardiopulmonary exercise testing was significantly correlated with E/E' (r=0.49; P<0.001) and added independent prognostic value (P<0.001).