Key result
The minor allele of rs4746172 in the VCL gene was significantly associated with a lower risk of hypertension in male Chinese subjects (OR 0.70), a finding that was replicated in an independent cohort.
Why the study?
Does the rs4746172 variant of the VCL gene associate with hypertension in Han Chinese populations?
Case-Control (n=2,312)
Yes
Does the rs4746172 variant of the VCL gene associate with hypertension in Han Chinese populations?
The rs4746172 variant of the VCL gene is associated with a lower risk of hypertension specifically in male Han Chinese individuals, suggesting a potential sex-specific genetic marker for cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Rs4746172 should not guide hypertension risk assessment; leaves open sex-specific VCL contributions in Han Chinese.
Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SNPs) in Europeans with hypertension in Chinese. A total of 1766 samples consisting of 880 subjects with hypertension and 886 controls were collected and the SNPs were genotyped using multiple assays based on the SNaPshot mini-sequencing approach. Our results revealed a significant genotypic association of rs4746172 of VCL with hypertension with a lower frequency of minor allele in male subjects (OR = 0.70, 95% CI: 0.54-0.92, p = 0.011) but not in females. To validate the result, we genotyped the SNPs in another Chinese population with 546 individuals, and got a consistent association for the rs4746172 (OR = 0.56, 95% CI: 0.38-0.82, p = 2.4 × 10(-3)) in males. The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese.
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Yu et al. (2015) conducted a case-control in Hypertension (n=2,312). rs4746172 minor allele of VCL gene vs. Major allele was evaluated on Hypertension in male subjects (OR 0.70, 95% CI 0.54-0.92, p=0.011). The minor allele of rs4746172 in the VCL gene was significantly associated with a lower risk of hypertension in male Chinese subjects (OR 0.70), a finding that was replicated in an independent cohort.
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