Key result
Carriers of the C-allele of the rs579459 variant had a significantly higher risk of recurrent MI or cardiac death within 5 years after an acute coronary syndrome (HR 1.80; 95% CI 1.09-2.95; P=0.021).
Why the study?
Does the rs579459 variant predict recurrent myocardial infarction or cardiac death in patients following an acute coronary syndrome?
Observational (n=3,349)
Yes
Does the rs579459 variant predict recurrent myocardial infarction or cardiac death in patients following an acute coronary syndrome?
Hazard Ratio: 1.8 (95% CI 1.09–2.95)
p-value: p=0.021
The rs579459 variant is independently associated with adverse cardiac outcomes after ACS and may weakly improve clinical risk prediction models.
The rs579459 C-allele was associated with higher recurrent risk after ACS; leaves open whether it improves clinical risk prediction.
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Wauters et al. (2012) conducted an observational in Acute coronary syndrome (ACS) (n=3,349). C-allele of the rs579459 variant vs. Non-carriers was evaluated on Recurrent MI or cardiac death (HR 1.80, 95% CI 1.09-2.95, p=0.021). Carriers of the C-allele of the rs579459 variant had a significantly higher risk of recurrent MI or cardiac death within 5 years after an acute coronary syndrome (HR 1.80; 95% CI 1.09-2.95; P=0.021).
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