Key result
Preincisional 1% bupivacaine injection significantly reduced mean pain scores at 2 hours post-surgery compared to no injection (3.1 vs 5.6, p=0.012) in patients undergoing appendectomy.
Why the study?
The study evaluated the effectiveness of preincisional and postoperative bupivacaine injections in reducing pain after appendectomy.
Does preincisional or postoperative bupivacaine injection reduce postoperative pain in acute appendicitis patients undergoing appendectomy?
Does preincisional or postoperative bupivacaine injection reduce postoperative pain in acute appendicitis patients undergoing appendectomy?
Absolute Event Rate: 3.1% vs 5.6%
p-value: p=0.012
Preincisional and postoperative bupivacaine injections may offer a safe and practical option for pain reduction after appendectomy, though differences in pain scores were not statistically significant in this small study.
Bupivacaine injections should not change post-appendectomy pain management; leaves open benefit in larger randomized trials.
Objective: This study evaluated the effectiveness of preincisional and postoperative bupivacaine injections in reducing pain after appendectomy.Methods: This quasi-experimental study included 60 acute appendicitis patients undergoing appendectomy at Vajira Hospital.Participants were randomly assigned to three groups: group 1 received a preincisional 10-mL injection of 1% bupivacaine, group 2 received a postoperative 10-mL injection of 1% bupivacaine, and group 3 (control) received no bupivacaine.Postoperative pain was assessed using the Visual Analog Scale at 2, 6, 12, and 24-hour post-surgery.Complications, including wound hematoma and surgical site infections, were recorded Results: Pain scores were lower in both preincisional and postoperative bupivacaine groups compared to the control across all time points, with group 1 showing the greatest reduction.However, the differences in pain scores were not statistically significant.No complications, such as wound hematoma or surgical site infections, were observed, indicating bupivacaine's safety.Conclusions: Preincisional and postoperative bupivacaine injections are effective and safe for reducing pain after appendectomy.Preincisional administration shows the best pain reduction and is a practical pain management option, especially in resource-limited settings.
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Sangkaprom et al. (2025) studied Acute appendicitis (n=60). Preincisional 1% bupivacaine injection vs. No injection (control) was evaluated on Mean postoperative pain score at 2 hours (p=0.012). Preincisional 1% bupivacaine injection significantly reduced mean pain scores at 2 hours post-surgery compared to no injection (3.1 vs 5.6, p=0.012) in patients undergoing appendectomy.
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