Key result
Postoperative bupivacaine prolongs analgesia to ~14 hours compared to preoperative infiltration or saline.
Why the study?
Modern anaesthesiologists focus on both intraoperative care and postoperative welfare, but optimal timing of bupivacaine infiltration for postoperative analgesia is unclear.
Does postoperative or preoperative infiltration with 0.25% bupivacaine improve postoperative analgesia in patients undergoing lower abdominal surgeries?
RCT (n=150)
Sealed envelope method
No
Does postoperative or preoperative infiltration with 0.25% bupivacaine improve postoperative analgesia in patients undergoing lower abdominal surgeries?
Absolute Event Rate: 14.28% vs 2.36%
p-value: p=<0.001
Postoperative infiltration of 0.25% bupivacaine provides a significantly longer duration and better quality of analgesia compared to preoperative infiltration in patients undergoing lower abdominal surgeries.
No takes yet. Share an insight, caveat, or question.
May influence postop analgesia timing; hypothesis-generating and requires RCTs before any practice consideration.
Gupta et al. (2021) conducted an RCT in Postoperative pain (n=150). Bupivacaine infiltration vs. Normal saline (control) and preoperative bupivacaine infiltration was evaluated on Duration of analgesia (p=<0.001). Postoperative infiltration with 0.25% bupivacaine significantly prolonged the duration of analgesia to a mean of 14.28 hours compared to 3.26 hours for preoperative infiltration and 2.36 hours for normal saline control.
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