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August 1, 1965Archives of Neurology

Hereditary Occurrence of Nemaline Myopathy

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Population

Patients with nemaline myopathy occurring in two generations of the same family, including a 10-year-old…

Design

Case_series

Authors

ASAlfred J. SpiroAlbert Einstein College of MedicineCKCharles KennedyUniversity of Strathclyde

Discussion

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Implication

Raises possibility of hereditary transmission; hypothesis-generating and requires confirmation in additional families.

Structured PICO

P
Population
Patients with nemaline myopathy occurring in two generations of the same family, including a 10-year-old white girl.
O
Outcome
Clinical features and pathological changes in muscles

This report provides the first proven evidence of hereditary occurrence of nemaline myopathy across two generations of a family.

Cite This Study

Spiro et al. (1965) studied this question.

synapsesocial.com/papers/6a9506d95426d440e59e650chttps://doi.org/10.1001/archneur.1965.00470020045006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NEMALINE MYOPATHY1963 · 469 citations
  2. 2Light and Electron Microscopic Studies of "Myogranules" in Child With Hypotonia and Muscle Weakness1963 · 165 citations
  3. 3THE DISTRIBUTION OF MUSCLE ANTIGENS IN CONTRACTED MYOFIBRILS DETERMINED BY FLUORESCEIN-LABELED ANTIBODIES1961 · 38 citations
  4. 4The essentiality of histo- and cytochemical studies of skeletal muscle in the investigation of neuromuscular disease1998 · 333 citations
  5. 5The Future of the ‘Floppy Infant‘: A Follow‐up Study of 133 Patients1963 · 37 citations