Key result
SSRI use was associated with an increased risk of hip fracture compared to no use, with marginal structural models yielding HRs of 2.15 (95% CI 1.30-3.55) and 1.63 (95% CI 1.28-2.07) in two cohorts.
Why the study?
Does SSRI use increase the risk of hip fracture in patients with a first prescription for antidepressants?
Cohort
Yes
Does SSRI use increase the risk of hip fracture in patients with a first prescription for antidepressants?
Hazard Ratio: 2.15 (95% CI 1.3–3.55)
In this methodological comparison, differences between statistical methods to control for time-dependent confounding were small, illustrating that adequate data on confounding is the most crucial factor to prevent bias.
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SSRI use was associated with higher hip fracture risk; leaves open residual confounding and underscores that adequate confounder data, not method choice, drives validity.
Ali et al. (2016) conducted a cohort in Antidepressant use and risk of hip fracture. Selective serotonin reuptake inhibitors (SSRIs) vs. No SSRI was evaluated on Hip fracture (HR 2.15, 95% CI 1.30-3.55). SSRI use was associated with an increased risk of hip fracture compared to no use, with marginal structural models yielding HRs of 2.15 (95% CI 1.30-3.55) and 1.63 (95% CI 1.28-2.07) in two cohorts.
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