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November 14, 2023Heart

Eosinophilic myocarditis: systematic review

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Key result

Among 274 cases of eosinophilic myocarditis, 82.4% were diagnosed by endomyocardial biopsy and 17.6% by cardiac MRI, with CMR-diagnosed patients exhibiting a better risk profile.

Why the study?

In clinical practice, patients with eosinophilic myocarditis may forgo the gold standard endomyocardial biopsy, highlighting the need to summarise current diagnostic and treatment approaches with emphasis on alternative diagnostic methods.

Population

274 cases from 239 articles including 8 observational studies

Design

Systematic review

Authors

WTWitina TechasatianMGMaan GozunKVKristine B. Vo

Discussion

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Overview

EMB remains the diagnostic mainstay for eosinophilic myocarditis; leaves optimal corticosteroid dosing open for prospective trials.

Study Design

Type

Systematic Review (n=274)

Structured PICO

P
Population
Systematic review of 239 articles including 8 observational studies and 274 cases of eosinophilic myocarditis.
E
Exposure
Diagnostic approaches (endomyocardial biopsy, cardiac MRI) and treatments (glucocorticoids)
O
Outcome
Approaches in diagnosing and treating eosinophilic myocarditis, with emphasis on the utilisation and value of alternative diagnostic methods

Main Result

Absolute Event Rate: 82.4% vs 17.6%

Endomyocardial biopsy remains the diagnostic mainstay for eosinophilic myocarditis, while cardiac MRI serves as a potentially helpful screening tool.

Cite This Study

Techasatian et al. (2023) conducted a systematic review in Eosinophilic myocarditis (n=274). Endomyocardial biopsy (EMB) vs. Cardiac MRI (CMR) was evaluated on Method of diagnosis. Among 274 cases of eosinophilic myocarditis, 82.4% were diagnosed by endomyocardial biopsy and 17.6% by cardiac MRI, with CMR-diagnosed patients exhibiting a better risk profile.

synapsesocial.com/papers/6a950dce77bd7906860f3268https://doi.org/10.1136/heartjnl-2023-323225
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Eosinophilic myocarditis in patients awaiting heart transplantation*2004 · 82 citations
  2. 2Cardiovascular MRI for Assessment of Infectious and Inflammatory Conditions of the Heart2011 · 39 citations
  3. 3Methodological quality and synthesis of case series and case reports2018 · 2,273 citations
  4. 4Acute eosinophilic myocarditis: Diagnosis and treatment2010 · 44 citations