Key result
Empiric IV steroids improve LVEF by ~10% in a patient with suspected biopsy-negative eosinophilic myocarditis.
Why the study?
Eosinophilic myocarditis is difficult to diagnose even with endomyocardial biopsy due to patchy myocardial infiltration, complicating treatment decisions.
Does empiric high-dose intravenous steroid treatment improve symptoms and cardiac function in suspected eosinophilic myocarditis with negative biopsy?
Comparison
Empiric high-dose intravenous steroids after negative endomyocardial biopsy
Design
Case report
Authors
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May support empiric steroids despite negative biopsy in suspected eosinophilic myocarditis; leaves open efficacy pending prospective data.
Case Report (n=1)
No
Does empiric high-dose intravenous steroid treatment improve symptoms and cardiac function in suspected eosinophilic myocarditis with negative biopsy?
Empiric high-dose steroid therapy may be beneficial and life-saving in suspected eosinophilic myocarditis even when endomyocardial biopsy is negative due to patchy infiltration.
Vaysblat et al. (2023) conducted a case report in Eosinophilic myocarditis (n=1). Intravenous methylprednisolone was evaluated on Left ventricular ejection fraction (LVEF). Empiric treatment with high-dose intravenous steroids improved left ventricular ejection fraction from 30% to 40% in a patient with suspected eosinophilic myocarditis despite a negative endomyocardial biopsy.
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