August 1, 1992Journal of VirologyOpen Access

Specificity of Rous sarcoma virus nucleocapsid protein in genomic RNA packaging

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Population

Rous sarcoma virus (RSV) clones and chimeric plasmids

Comparison

Substitution of the nucleocapsid coding region… vs Wild type RSV and a mutant of RSV with…

Design

Preclinical

Authors

PDPhilippe DuprazMerck (Germany)PSP F SpahrUniversity of Geneva

Discussion

Member takes

Implication

NC protein contributes to selective RNA packaging; extends mechanistic models of retroviral assembly in animal systems.

Structured PICO

Population

Rous sarcoma virus (RSV) clones and chimeric plasmids

Intervention

Substitution of the nucleocapsid (NC) coding region, the psi RNA packaging sequence, or both from Moloney murine leukemia virus (MoMuLV) into a full-length RSV clone

Comparator

Wild type RSV and a mutant of RSV with completely deleted NC

Outcome

Viral RNA packaging specificity, virus assembly, and infectivitysurrogate

The specific recognition of viral RNA during virus assembly involves, at least in part, the nucleocapsid protein.

Cite This Study

Dupraz et al. (1992) studied this question.

synapsesocial.com/papers/6a950fb2dd1b902261fa56da https://doi.org/10.1128/jvi.66.8.4662-4670.1992

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Specificity of Rous sarcoma virus nucleocapsid protein in genomic RNA packaging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specificity of Rous sarcoma virus nucleocapsid protein in genomic RNA packaging

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider