Key result
Experimental chronic heart failure induced by myocardial infarction in mice caused persistent anhedonia, reduced exploratory activity, and cognitive impairment, alongside dysregulation of inflammatory genes in the brain.
p-value: p=0.029
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Heart failure may contribute to anhedonia and cognitive impairment via brain inflammation; leaves open human translation and therapeutic targets.
Frey et al. (2014) studied Chronic heart failure (n=29). Coronary artery ligation (Myocardial Infarction) vs. Sham operation was evaluated on Sucrose preference (anhedonia) (p=0.029). Experimental chronic heart failure induced by myocardial infarction in mice caused persistent anhedonia, reduced exploratory activity, and cognitive impairment, alongside dysregulation of inflammatory genes in the brain.
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