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August 4, 2020Open Access

Heart failure induced by coronary artery ligation in rats resulted in significant impairments in mood and memory, accompanied by a drastic downregulation of synaptic plasticity genes in the prefrontal cortex and paraventricular nucleus.

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Why the study?

Few studies have assessed the effects of severely reduced ejection fraction on cognition in animal models, with limited information on synaptic plasticity genetic markers in memory and mood brain regions.

Population

Male rats

Comparison

Induced heart failure vs control

Design

Animal experimental study

Key result

Heart failure induced by coronary artery ligation in rats resulted in significant impairments in mood and memory, accompanied by a drastic downregulation of synaptic plasticity genes in the prefrontal cortex and paraventricular nucleus.

Authors

MPMarise B. ParentHFHildebrando Candido Ferreira‐NetoAKAna Rafaela Kruemmel

Discussion

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Overview

Preclinical rat data on HF-related mood and cognitive deficits warrant no clinical changes; leaves open human relevance of identified synaptic pathways.

Structured PICO

P
Population
Male Wistar rats subjected to coronary artery ligation to induce heart failure, evaluated for mood, memory, and brain gene expression 5-10 weeks post-surgery.
I
Intervention
Heart failure (HF) induced by coronary artery ligation (left anterior descending coronary artery)
C
Comparator
Sham control animals (same surgical procedure without coronary artery occlusion)
O
Outcome
Mood and anxiety (sucrose preference test, elevated plus maze), memory (spontaneous alternation, inhibitory avoidance), and expression of 84 synaptic plasticity-associated genes in multiple brain regionssurrogate

Main Result

p-value: p=0.026

Heart failure with severely reduced ejection fraction in rats induces significant mood and memory deficits accompanied by profound downregulation of synaptic plasticity genes in the prefrontal cortex and paraventricular nucleus.

Limitations

  • Animal model may not fully replicate human heart failure
  • Arbitrary threshold of +/- 40% change used for qualitative gene expression analysis

Cite This Study

Parent et al. (2020) studied Heart failure. Coronary artery ligation (Heart failure induction) vs. Sham surgery was evaluated on Alternations between arms in the Y-maze (spatial working memory) (p=0.026). Heart failure induced by coronary artery ligation in rats resulted in significant impairments in mood and memory, accompanied by a drastic downregulation of synaptic plasticity genes in the prefrontal cortex and paraventricular nucleus.

synapsesocial.com/papers/6a5f84a343fbe6fe485ff07chttps://doi.org/10.1101/2020.08.03.234831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetic gene expression links heart failure to memory impairment2021 · 30 citations
  2. 2Epigenetic gene-expression links heart failure to memory impairment2020 · 2 citations
  3. 3Angiotensin II–Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats2023 · 36 citations
  4. 4Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain2014 · 50 citations
  5. 5Impaired oxytocin signaling in the central amygdala in rats with chronic heart failure2023