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April 10, 2023HypertensionOpen Access

Blockade of AT1Rs with Losartan efficiently reversed neuroinflammatory end points and improved cognitive performance in HF rats.

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Why the study?

The underlying neuronal substrates, mechanisms, and relative contribution of neuroinflammation and brain hypoperfusion to cognitive deficits in heart failure remained unknown.

Does Losartan reduce neuroinflammation and improve cognitive performance in a rat model of heart failure?

Population

HF rat model

Comparison

AT1R blockade with Losartan vs untreated or baseline HF rats

Design

Preclinical animal study

Authors

FAFerdinand AlthammerRRRanjan K. RoyMKMatthew K. Kirchner

Discussion

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Overview

Losartan effects in rat HF model warrant no clinical change; leaves open translation to human neuroprotection.

Structured PICO

Does Losartan reduce neuroinflammation and improve cognitive performance in a rat model of heart failure?

P
Population
Heart failure rat model
I
Intervention
Losartan (AT1R blockade)
C
Comparator
Control/vehicle (implied)
O
Outcome
Neuroinflammatory endpoints and cognitive performancesurrogate

Blockade of AT1 receptors with losartan reverses neuroinflammation and improves cognitive performance in a rat model of heart failure, highlighting a potential neuroprotective mechanism.

Cite This Study

Althammer et al. (2023) studied this question.

synapsesocial.com/papers/6a7df7a4143763190a3ca0e2https://doi.org/10.1161/hypertensionaha.123.21070
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Also Consider

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  1. 1Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure2024 · 8 citations
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  4. 4Neuroinflammation in heart failure: new insights for an old disease2019 · 105 citations
  5. 5Angiotensin II‐mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats2023 · 16 citations