Key result
Administration of a drug promoting neuronal euchromatin formation ameliorated memory impairment and pathological hippocampal gene expression changes in a mouse model of heart failure.
Why the study?
Cognitive dysfunction is a severe burden in heart failure patients, but the underlying molecular mechanisms and corresponding therapeutic strategies are unknown.
Does a drug that promotes neuronal euchromatin formation improve memory function in mice with heart failure?
Population
Mice as model organisms suffering from heart failure
Comparison
Administration of a drug that promotes neuronal euchromatin formation vs unstated comparator
Design
Preclinical animal study
Authors
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Hypothesis-generating for epigenetic therapies in heart failure cognitive impairment; leaves open human translation from this mouse model.
Does a drug that promotes neuronal euchromatin formation improve memory function in mice with heart failure?
This study provides preclinical evidence that heart failure-induced cognitive defects are linked to epigenetic changes in the hippocampus, which can be ameliorated by drugs promoting neuronal euchromatin formation.
Islam et al. (2021) studied Heart failure and memory impairment. Drug that promotes neuronal euchromatin formation was evaluated on Hippocampal gene expression and memory function. Administration of a drug promoting neuronal euchromatin formation ameliorated memory impairment and pathological hippocampal gene expression changes in a mouse model of heart failure.
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