Why the study?
Cognitive dysfunction is a severe burden in heart failure patients, but the underlying molecular mechanisms linking the two conditions and corresponding therapeutic strategies were unknown.
Does Vorinostat improve memory function and restore hippocampal gene expression in a mouse model of heart failure?
Population
Mice
Design
Preclinical animal model study
Key result
Administration of the HDAC inhibitor Vorinostat ameliorated memory impairment and partially restored physiological hippocampal gene expression in a mouse model of heart failure.
Authors
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May support HDAC inhibition for heart failure-related cognitive impairment; hypothesis-generating in mice and leaves open human translation.
Does Vorinostat improve memory function and restore hippocampal gene expression in a mouse model of heart failure?
Heart failure induces cognitive impairment via epigenetic changes in hippocampal gene expression, which can be ameliorated by the HDAC inhibitor Vorinostat in a mouse model.
Islam et al. (2020) studied Heart failure-induced memory impairment (n=29). Vorinostat vs. Vehicle was evaluated on Spatial reference memory (Barnes Maze escape latency). Administration of the HDAC inhibitor Vorinostat ameliorated memory impairment and partially restored physiological hippocampal gene expression in a mouse model of heart failure.
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