What question did this study set out to answer?

To evaluate the therapeutic potential of phosphoethanolamine-bound C-reactive protein in capturing atherogenic low-density lipoproteins and inhibiting macrophage foam cell formation in atherosclerosis.

November 28, 2008Future Lipidology

Therapeutic potential of phosphoethanolamine-bound C-reactive protein in atherosclerosis

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Authors

AAAlok AgrawalAll India Institute of Medical Sciences Raipur

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Implication

Preclinical research demonstrates that phosphoethanolamine-bound C-reactive protein blocks foam cell formation in macrophages, indicating therapeutic utility against atherosclerosis.

Key Points

To evaluate the therapeutic potential of phosphoethanolamine-bound C-reactive protein in capturing atherogenic low-density lipoproteins and inhibiting macrophage foam cell formation in atherosclerosis.
Laboratory synthesis evaluating the binding affinity of phosphoethanolamine and phosphoethanolamine-bound C-reactive protein to native low-density lipoprotein in human serum.
In vitro interaction assays measuring the binding capacity to enzymatically-modified low-density lipoprotein and subsequent macrophage foam cell formation.
Phosphoethanolamine-bound C-reactive protein effectively captured native low-density lipoprotein in human serum.
Binding of phosphoethanolamine-bound C-reactive protein to enzymatically-modified low-density lipoprotein was markedly more potent than unbound C-reactive protein, preventing lipid-loaded foam cell generation.

Cite This Study

Alok Agrawal (2008) studied this question.

synapsesocial.com/papers/6a95159d57dad826d8f58e4b https://doi.org/10.2217/17460875.3.6.599

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Implication

Preclinical research demonstrates that phosphoethanolamine-bound C-reactive protein blocks foam cell formation in macrophages, indicating therapeutic utility against atherosclerosis.

Therapeutic potential of phosphoethanolamine-bound C-reactive protein in atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Therapeutic potential of phosphoethanolamine-bound C-reactive protein in atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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