CGC enantiomer separation on diluted cyclodextrin derivatives coated on fused silica columns

High‐resolution capillary gas chromatographic separation of enantiomers, belonging to different classes of compounds on cyclodextrin derivatives is described. The solutions of heptakis (2,3,6‐O‐trimethyl)‐β‐cyclodextrin (Phase I), heptakis (2,6‐O‐dimethyl‐3‐O‐trifluoro‐acetyl)‐β‐cyclodextrin (Phase II) and heptakis (2,6‐O‐dimethyl‐3‐O‐heptafluorobutyryl)‐β‐cyclodextrin (Phase III) in the moderately polar polysiioxane OV‐1701 were coated onto deactivated fused silica capillaries furnishing columns of high efficiency. The three phases show different enantioselectivities for various racemic mixtures.