Philadelphia Chromosome Abnormality in Agnogenic Myeloid Metaplasia

Case Studies1 March 1966Philadelphia Chromosome Abnormality in Agnogenic Myeloid MetaplasiaRALPH H. FORRESTER, JOSE M. LOURORALPH H. FORRESTERSearch for more papers by this author, JOSE M. LOUROSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1960, Nowell and Hungerford (1) described a chromosome change in chronic granulocytic leukemia which has since been confirmed by numerous workers and termed the Philadelphia chromosome (Ph1) abnormality. It consists of a loss either by deletion or translocation of approximately half of the genetic material occupying the long arms of one of the small acrocentric chromosomes. The change is illustrated schematically in Figure 1. Chromosome abnormalities of many types have been observed in leukemia (2, 3). There have been too many chromosomes, too few, and a variety of qualitative abnormalities (4). The Ph1has been unique in that it...References1. NOWELLHUNGERFORD PCDA: Minute chromosome in human chronic granulocytic leukemia. Science 132: 1497, 1960. Google Scholar2. FORDJACOBSLAJTHA CEPALG: Human somatic chromosomes. Nature (London) 181: 1565, 1958. CrossrefMedlineGoogle Scholar3. BAIKIECOURT BROWNJACOBSMILNE AGWMPAJS: Chromosome studies in human leukaemia. Lancet 2: 425, 1959. CrossrefMedlineGoogle Scholar4. GUNZFITZGERALD FWPH: Editorial: Chromosomes and leukemia. Blood 23: 394, 1964. CrossrefMedlineGoogle Scholar5. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar6. TOUGHCOURT BROWNBAIKIEBUCKTONHARNDENJACOBSKINGMCBRIDE IMWMAGKEDGPAMJJA: Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with mongolism. Lancet 1: 411, 1961. CrossrefMedlineGoogle Scholar7. TOUGHCOURT BROWNBAIKIEBUCKTONHARNDENJACOBSWILLIAMS IMWMAGKEDGPAJA: Chronic myeloid leukaemia: cytogenetic studies before and after splenic irradiation. Lancet 2: 115, 1962. CrossrefMedlineGoogle Scholar8. SANDBERGISHIHARACROSSWHITEHAUSCHKA AATLHTS: Comparison of chromosome constitution in chronic myelocytic leukemia and other myeloproliferative disorders. Blood 20: 393, 1962. CrossrefMedlineGoogle Scholar9. NOWELLHUNGERFORD PCDA: Chromosome changes in human leukemia and a tentative assessment of their significance. Ann. N. Y. Acad. Sci. 113: 654, 1964. CrossrefMedlineGoogle Scholar10. FITZGERALDADAMSGUNZ PHAFW: Chronic granulocytic leukemia and the Philadelphia chromosome. Blood 21: 183, 1963. CrossrefMedlineGoogle Scholar11. SPEEDLAWLER DESD: Chronic granulocytic leukaemia. The chromosomes and the disease. Lancet 1: 403, 1964. CrossrefMedlineGoogle Scholar12. TOUGHJACOBSCOURT BROWNBAIKIEWILLIAMSON IMPAWMAGER: Cytogenetic studies on bone-marrow in chronic myeloid leukemia. Lancet 1: 844, 1963. CrossrefMedlineGoogle Scholar13. GOHSWISHER KSN: Specificity of the Philadelphia chromosome: cytogenetic studies in cases of chronic myelocytic leukemia and myeloid metaplasia. Ann. Intern. Med. 61: 609, 1964. LinkGoogle Scholar14. TIPSSMITHMEYERUSHIJIMA RLGSDLRN: Karyotype analysis of leucocytes as a practical laboratory procedure. Texas Rep. Biol. Med. 21: 581, 1963. MedlineGoogle Scholar15. DAMESHEK W: Some speculations on the myeloproliferative syndromes. Blood 6: 372, 1951. CrossrefMedlineGoogle Scholar16. KRAUSSSOKALSANDBERG SJEAA: Comparison of Philadelphia chromosome-positive and -negative patients with chronic myelocytic leukemia. Ann. Intern. Med. 61: 625, 1964. LinkGoogle Scholar17. XEFTERISMITUSMEDNICOFFDAMESHEK EWJIBW: Leukocytic alkaline phosphatase in busulfan-induced remissions of chronic granulocytic leukemia. Blood 18: 202, 1961. CrossrefMedlineGoogle Scholar18. MALONEYLANGE WCRD: Leukemia in atomic bomb survivors. II. Observations on early phases of leukemia. Blood 9: 663, 1954. CrossrefMedlineGoogle Scholar19. KEMPSTAFFORDTANNER NHJLR: Aetiology of leukaemias. Lancet 2: 95, 1963. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RALPH H. FORRESTER; JOSE M. LOUROAffiliations: Fort Sam Houston, TexasFrom the Department of Medicine, Brooke General Hospital, Brooke Army Medical Center, Fort Sam Houston, Tex.This study was presented at the Regional Meeting of the American College of Physicians, Dallas, Tex., December 13, 1964.Requests for reprints should be addressed to Colonel Ralph H. Forrester, MC, Department of Medicine, Brooke General Hospital, Fort Sam Houston, Tex. 78234. 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WALKER, M.D.Genetic Factors in CarcinomaTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSTHE PHILADELPHIA CHROMOSOME AND LEUKOCYTE ALKALINE PHOSPHATASE IN CHRONIC MYELOCYTIC LEUKEMIA AND RELATED DISORDERSHYPOGLYCÆMIC EFFECT OF TRIGONELLINESPECIFICITY OF THE Ph1 CHROMOSOME 1 March 1966Volume 64, Issue 3Page: 622-627KeywordsChromosomal translocationsChromosomesCytogeneticsGeneticsHospital medicinePhosphatases ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...