Why the study?
Does ketamine induction impair spontaneous baroreflex sensitivity in healthy humans?
Does ketamine induction impair spontaneous baroreflex sensitivity in healthy humans?
Anesthesia induction with ketamine significantly impairs baroreflex control of heart rate in healthy individuals, which may provoke hemodynamic instability.
May warrant caution with ketamine induction in hemodynamically vulnerable patients; leaves open clinical relevance pending randomized confirmation.
Background: It is reported that ketamine increases central sympathetic activity as well as catecholamine reuptake inhibition. However, little has been known about baroreflex control of heart rate in ketamine anesthetized humans. Thus, the aim of this study was to analyze the effect of ketamine on spontaneous baroreflex sensitivity (BRS) during ketamine induction of anesthesia.
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Song et al. (2006) studied this question.
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