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May 17, 2004Angewandte Chemie

Highly Diastereo‐ and Enantioselective Reactions of Enecarbamates with Ethyl Glyoxylate To Give Optically Active syn and anti α‐Alkyl‐β‐Hydroxy Imines and Ketones

Ryosuke Matsubara Yoshitaka Nakamura Shü Kobayashi

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Abstract

Die bemerkenswert selektive Addition von Encarbamaten 2 in Gegenwart eines Kupfer-Diimin-Katalysators (0.1 Mol-%) an Ethylglyoxylat (1) liefert die Imine 3 in hohen Ausbeuten und mit ausgezeichneten Enantioselektivitäten. Zur Erklärung des stereochemischen Verlaufs wurde ein Reaktionsmechanismus ähnlich dem einer konzertierten Aza-En-Reaktion vorgeschlagen.

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Matsubara et al. (2004) studied this question.

synapsesocial.com/papers/6a95255e3d7e4fca39b2d4dd https://doi.org/10.1002/ange.200460165

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