Filling the gap. Abasic sites represent a frequently occurring lesion in DNA. If not repaired, such lesions can lead to mutations or cell death. Stabilization of DNA containing abasic sites is investigated as a therapeutic approach for the treatment of cancer. Non-nucleosidic phenanthroline and pyrene derivatives were found to have a profound stabilizing effect (ΔTm=8 °C) on DNA missing a nucleobase.
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Langenegger et al. (2005) studied this question.
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