July 1, 1994Cardiovascular Research

Low incidence of ventricular arrhythmias induced by ischaemia at the borders of a chronic infarct in a model with local postinfarction denervation

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Population

Pigs subjected to acute ischaemia with or without a one-month-old chronic anteroseptal infarction.

Comparison

Acute ischaemia superimposed at the borders of a… vs Acute ischaemia alone.

Design

Preclinical

Follow-up

60 minutes

Authors

JCJuan CincaHospital de Sant Pau ABAlfredo Bardajı́General Cardiology ACA Carreño

Discussion

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Implication

Does not support changes in post-MI ischaemia care; leaves open whether border denervation protects against human VF.

Structured PICO

Population

Pigs (n=56 total across experiments) subjected to acute ischaemia with or without a one-month-old chronic anteroseptal infarction.

Intervention

Acute ischaemia superimposed at the borders of a chronic myocardial infarct (60 min occlusion of the left anterior descending coronary artery 2 cm above the first diagonal branch in pigs with a one-month-old infarct).

Comparator

Acute ischaemia alone (60 min occlusion of the left anterior descending coronary artery high or low).

Outcome

Incidence of ventricular arrhythmias (ventricular fibrillation, ventricular tachycardia, ventricular premature beats) during 60 min occlusion.surrogate

In a porcine model, acute ischaemia at the borders of a chronic infarct has a low arrhythmogenic potential, which is associated with local sympathetic and parasympathetic denervation secondary to necrosis.

Cite This Study

Cinca et al. (1994) studied this question.

synapsesocial.com/papers/6a952b4c95cf49f4209e73e8 https://doi.org/10.1093/cvr/28.7.1018

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Low incidence of ventricular arrhythmias induced by ischaemia at the borders of a chronic infarct in a model with local postinfarction denervation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low incidence of ventricular arrhythmias induced by ischaemia at the borders of a chronic infarct in a model with local postinfarction denervation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider