What question did this study set out to answer?

To investigate the feasibility, procedural technique, and 12-month outcomes of the radial force-independent LuX-Valve in patients with severe functional tricuspid regurgitation.

November 1, 2021EuroInterventionOpen Access

Twelve-month outcomes of the LuX-Valve for transcatheter treatment of severe tricuspid regurgitation

View Full Paper

Ask AI

Bookmark

Why the study?

Severe functional tricuspid regurgitation is associated with adverse outcomes and high surgical risk in advanced stages, requiring alternative approaches such as transcatheter valve replacement.

Does transcatheter tricuspid valve replacement with the LuX-Valve improve tricuspid regurgitation and right ventricular function in patients with severe functional tricuspid regurgitation?

Key Points

To investigate the feasibility, procedural technique, and 12-month outcomes of the radial force-independent LuX-Valve in patients with severe functional tricuspid regurgitation.
Prospective interventional evaluation in N=6 patients with secondary massive tricuspid regurgitation and previous left-sided valvular surgery.
LuX-Valve devices were implanted transatrially under digital subtraction angiography and transoesophageal echocardiographic guidance.
Right heart dimensions, conventional right ventricular function parameters, and right ventricular global longitudinal strain were evaluated through 12-month follow-up.
All 6 patients achieved successful valve delivery with immediate, substantial reduction in tricuspid regurgitation severity.
One patient died from right heart failure associated with moderate paravalvular leakage at 3 months post-procedure.
The 5 surviving patients had no significant paravalvular leakage and showed significant improvements in mean transvalvular gradient, right heart size, right ventricular strain, and NYHA class at 12 months.

Structured PICO

Does transcatheter tricuspid valve replacement with the LuX-Valve improve tricuspid regurgitation and right ventricular function in patients with severe functional tricuspid regurgitation?

Population

6 patients with left-sided valvular surgery and secondary massive tricuspid regurgitation.

Intervention

Transcatheter tricuspid valve replacement with the LuX-Valve (a novel radial force-independent orthotopic transcatheter tricuspid valve) implanted through the right atrium.

Outcome

Feasibility, technical details, and midterm outcomes including degree of tricuspid regurgitation, right ventricular function parameters, and NYHA Functional Class at 12-month follow-up.surrogate

Transcatheter tricuspid valve replacement with the LuX-Valve appears feasible and may improve right ventricular function and symptoms in high-surgical-risk patients with severe functional tricuspid regurgitation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for LuX-Valve; leaves open efficacy, durability, and role versus alternatives pending randomized trials.

Cite This Study

Sun et al. (2021) studied this question.

synapsesocial.com/papers/6a9533570da585886d76a024 https://doi.org/10.4244/eij-d-21-00095

Topics

Tricuspid regurgitation

View Full Paper

Ask AI

Bookmark

Twelve-month outcomes of the LuX-Valve for transcatheter treatment of severe tricuspid regurgitation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Twelve-month outcomes of the LuX-Valve for transcatheter treatment of severe tricuspid regurgitation

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider