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March 1, 2002American Journal of Therapeutics

Does Heart Rate Identify Sudden Death Survivors?

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Why the study?

Does circadian variability of heart rate and other electrocardiographic variables distinguish sudden cardiac death survivors from matched controls and healthy subjects?

Population

42 subjects comprising 14 sudden death survivors, 14 control patients with diagnosis and therapy matched to…

Comparison

24-hour Holter monitoring with computer-assisted… vs Comparisons among the three groups

Design

Case-control

Authors

JMJános MolnárHawaii Community CollegeJWJerry WeissTel Aviv Sourasky Medical CenterJRJames E. RosenthalSwiss Center for Electronics and Microtechnology (Switzerland)

Discussion

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Implication

May identify sudden death survivors via blunted nocturnal HR decline; leaves open whether circadian HRV improves risk stratification in prospective studies.

Structured PICO

Does circadian variability of heart rate and other electrocardiographic variables distinguish sudden cardiac death survivors from matched controls and healthy subjects?

P
Population
42 subjects comprising 14 sudden death survivors, 14 control patients with diagnosis and therapy matched to survivors, and 14 healthy subjects.
I
Intervention
24-hour Holter monitoring with computer-assisted continuous QT measurement and heart rate variability analysis
C
Comparator
Comparisons among the three groups (sudden death survivors, matched heart disease controls, and healthy subjects)
O
Outcome
Circadian variability of electrocardiographic variables including heart rate, heart rate variability, and QT intervalsurrogate

Reduced circadian variation of heart rate, specifically a blunted nighttime decline, can identify sudden cardiac death survivors as effectively as complex heart rate variability measures.

Cite This Study

Molnár et al. (2002) studied this question.

synapsesocial.com/papers/6a95346f2dd91e6efbf2258dhttps://doi.org/10.1097/00045391-200203000-00004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1QT interval variables from 24 hour electrocardiography and the two year risk of sudden death.1993 · 179 citations
  2. 2Decreased heart rate variability and its association with increased mortality after acute myocardial infarction1987 · 4,025 citations
  3. 3QT interval prolongation as predictor of sudden death in patients with myocardial infarction.1978 · 764 citations
  4. 4Prognostic value and physiological correlates of heart rate variability in chronic severe mitral regurgitation.1993 · 134 citations
  5. 5HEART RATE AS A PROGNOSTIC FACTOR FOR CORONARY HEART DISEASE AND MORTALITY: FINDINGS IN THREE CHICAGO EPIDEMIOLOGIC STUDIES1980 · 561 citations