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February 6, 2013The Journal of Clinical Endocrinology & MetabolismOpen Access

Adolescents with prediabetes had 30% higher HFF (P = .001) and 31% higher PFF (P = .042) than those with normal glucose tolerance; PFF predicted prediabetes in African Americans (66% increased odds per 1% increase) and HFF predicted prediabetes in Latinos (22% increased odds per 1% increase).

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Population

148 healthy, overweight/obese adolescents, including 106 with normal glucose tolerance and 42 with…

Design

Cross-sectional

Authors

CTClaudia M. Toledo‐CorralTATanya L. AlderetePHPeng Hu

Discussion

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Overview

Ectopic fat deposition associates with adolescent prediabetes and varies by ethnicity; hypothesis-generating, requiring longitudinal studies before clinical consideration.

Structured PICO

P
Population
148 healthy, overweight/obese adolescents (56 African American, 92 Latino; 72 males, 76 females; mean age 15.5 ± 1.2 years; BMI z-score 2.1 ± 0.5), including 106 with normal glucose tolerance and 42 with prediabetes.
O
Outcome
Association of visceral adipose tissue (VAT), hepatic fat fraction (HFF), and pancreatic fat fraction (PFF) with prediabetessurrogate

Ectopic fat phenotypes associated with prediabetes are established by adolescence and differ by ethnicity, with pancreatic fat driving risk in African Americans and hepatic fat in Latinos.

Cite This Study

Toledo‐Corral et al. (2013) studied this question.

synapsesocial.com/papers/6a95348e229856c3dd16945fhttps://doi.org/10.1210/jc.2012-3806
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