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April 17, 2008Magnetic Resonance in MedicineOpen Access

Assessment of lipids in skeletal muscle by high‐resolution spectroscopic imaging using fat as the internal standard: Comparison with water referenced spectroscopy

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Why the study?

Does high-spatial-resolution MRSI compare favorably with single-voxel MRS for determining lipid content in human skeletal muscle?

Population

Human skeletal muscle

Comparison

High-spatial-resolution spectroscopic imaging… vs Proton single-voxel MR spectroscopy using…

Design

Other

Authors

JWJoachim WeisUniversitätsklinikum AachenLJLars JohanssonLinköping UniversityFOFrancisco Ortiz‐NietoUppsala University

Discussion

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Implication

High-resolution MRSI may aid muscle lipid quantification; leaves open standardization and clinical outcome validation.

Structured PICO

Does high-spatial-resolution MRSI compare favorably with single-voxel MRS for determining lipid content in human skeletal muscle?

P
Population
Human skeletal muscle
I
Intervention
High-spatial-resolution spectroscopic imaging (MRSI) using yellow bone marrow (internal) or vegetable oil (external) as fat standards
C
Comparator
Proton (1H) single-voxel MR spectroscopy (MRS) using unsuppressed water line as reference
O
Outcome
Lipid concentration in human skeletal musclesurrogate

High-resolution MRSI using fat as an internal or external standard is recommended over standard single-voxel MRS for measuring skeletal muscle lipid content to avoid relaxation correction issues.

Cite This Study

Weis et al. (2008) studied this question.

synapsesocial.com/papers/6a953588d33c5efb307cf96chttps://doi.org/10.1002/mrm.21601
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution2006 · 22 citations
  2. 2Water referencing for spectroscopic imaging1989 · 47 citations
  3. 3Localized Proton NMR spectroscopy using stimulated echoes: Applications to human skeletal muscle in vivo1991 · 149 citations
  4. 4Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging2004 · 79 citations