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September 1, 1999Journal of the American Society of Nephrology

Heart Rate Variability during Chronic Hemodialysis and after Renal Transplantation

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Why the study?

Does renal transplantation improve heart rate variability in patients on chronic hemodialysis compared to healthy controls?

Population

Patients on maintenance hemodialysis with no evidence of ischemic or hypertensive heart diseases, patients…

Comparison

Renal transplantation (observational state) vs Chronic hemodialysis and age- and gender-matched…

Design

Cross-sectional

Authors

DRDvora RubingerHadassah Medical CenterDSDan SapoznikovHadassah Medical CenterAPArthur PollakBrigham and Women's Hospital

Discussion

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Overview

Suggests uremic autonomic dysfunction may be reversible after transplant; hypothesis-generating, should not yet change practice or transplant timing.

Structured PICO

Does renal transplantation improve heart rate variability in patients on chronic hemodialysis compared to healthy controls?

P
Population
Patients on maintenance hemodialysis with no evidence of ischemic or hypertensive heart diseases, patients with systemic amyloidosis, patients after successful renal transplantation, and age- and gender-matched healthy individuals.
I
Intervention
Renal transplantation (observational state)
C
Comparator
Chronic hemodialysis and age- and gender-matched healthy individuals
O
Outcome
Heart rate variability (HRV) values, quantified as ultra low frequency, very low frequency, low frequency, and high frequency powers via spectral analyses of RR intervals from continuous electrocardiogram recordingssurrogate

Renal transplantation normalizes the significantly reduced heart rate variability seen in chronic hemodialysis patients, suggesting that uremic autonomic dysfunction is reversible.

Cite This Study

Rubinger et al. (1999) studied this question.

synapsesocial.com/papers/6a953870d33c5efb307cfa5chttps://doi.org/10.1681/asn.v1091972
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An investigation of the effect of advancing uraemia, renal replacement therapy and renal transplantation on blood pressure diurnal variability1997 · 165 citations
  2. 2IMPACT OF AUTONOMIC NEUROPATHY ON CIRCULATORY INSTABILITY DURING LIVER TRANSPLANTATION FOR FAMILIAL AMYLOIDOTIC POLYNEUROPATHY11997 · 42 citations
  3. 3Reduced chronotropic responsiveness of the heart in experimental uremia1986 · 25 citations
  4. 4Downregulation of nitric oxide synthase in chronic renal insufficiency: role of excess PTH1998 · 174 citations
  5. 5Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins1999 · 352 citations