What question did this study set out to answer?

To compare maternal and perinatal outcomes between women with pregestational and gestational diabetes mellitus, while evaluating the independent contributions of maternal obesity and gestational weight gain.

July 1, 2001QJM

Maternal and neonatal outcomes in pregestational and gestational diabetes mellitus, and the influence of maternal obesity and weight gain: the DEPOSIT study

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Authors

JRJoel G. RaySt. Michael's Hospital

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Implication

Prospective cohort study reveals increased complication rates in women with pregestational versus gestational diabetes, highlighting the additive harm of maternal obesity.

Key Points

To compare maternal and perinatal outcomes between women with pregestational and gestational diabetes mellitus, while evaluating the independent contributions of maternal obesity and gestational weight gain.
Prospective cohort study evaluating 624 consecutive singleton pregnancies delivered over 5 years at a single center, comprising 428 women with gestational diabetes mellitus and 196 women with pregestational diabetes mellitus.
Multivariable logistic regression models controlled for maternal body mass index, gestational weight gain, and additional clinical risk factors.
Women with pregestational diabetes had significantly higher risks of Caesarean delivery (OR 3.6, 95% CI 2.3–5.6), shoulder dystocia or cephalopelvic disproportion (OR 2.2, 95% CI 1.3–3.6), and gestational hypertension or toxaemia (OR 3.0, 95% CI 1.7–5.4) compared with gestational diabetes.
Offspring of mothers with pregestational diabetes showed greater risks of neonatal intensive care unit admission (OR 4.0, 95% CI 2.3–6.8), large-for-gestational-age birthweight (OR 3.5, 95% CI 2.2–5.6), and preterm birth before 37 weeks (OR 3.8, 95% CI 2.5–5.9).
Maternal obesity and excessive weight gain represented independent risk factors for adverse maternal and neonatal outcomes across both diabetes cohorts, except for shoulder dystocia and cephalopelvic disproportion.

Cite This Study

Joel G. Ray (2001) studied this question.

synapsesocial.com/papers/6a95392c6a42edee3f2ca1a1 https://doi.org/10.1093/qjmed/94.7.347

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Implication

Prospective cohort study reveals increased complication rates in women with pregestational versus gestational diabetes, highlighting the additive harm of maternal obesity.

Maternal and neonatal outcomes in pregestational and gestational diabetes mellitus, and the influence of maternal obesity and weight gain: the DEPOSIT study

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal and neonatal outcomes in pregestational and gestational diabetes mellitus, and the influence of maternal obesity and weight gain: the DEPOSIT study

Discussion

Member takes

Implication

Key Points

Cite This Study

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