Population
Human glomerular endothelial cells (GEC)
Design
Preclinical
Authors
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May inform mechanisms of hyperglycemia-induced endothelial dysfunction; hypothesis-generating and requires in vivo validation before clinical consideration.
High glucose and angiotensin II, but not free fatty acids, upregulate COX-2 via reactive oxygen species in human glomerular endothelial cells, highlighting differential pathways in early hyperglycemia.
Jaimes et al. (2009) studied this question.
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