This review summarizes early experimental and clinical evidence for the use of radiolabeled MIBG to noninvasively image cardiac sympathetic innervation.
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Early MIBG evidence for cardiac sympathetic imaging remains hypothesis-generating; prospective validation required before clinical adoption.
Catecholamines have profound influences on cardiac function. Mechanisms relating abnormalities in sympathetic innervation to myocardial dysfunction are poorly understood, however. Recent studies have demonstrated the feasibility of noninvasively imaging the sympathetic nerves of the heart using radiolabeled MIBG. This article examines some of the experimental evidence to support the neuronal localization of MIBG. In addition, the early clinical experience is reviewed.
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Dae et al. (1990) studied this question.
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