October 1, 1995British Journal of Haematology

Recombinant PDGF enhances megakaryocytopoiesis in vitro

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Why the study?

Does recombinant PDGF stimulate megakaryocyte colony formation in vitro?

Structured PICO

Does recombinant PDGF stimulate megakaryocyte colony formation in vitro?

Population

Murine and human megakaryocyte colony formation in a plasma clot culture system

Intervention

Recombinant platelet-derived growth factor (PDGF) (10 to 50 ng/ml)

Comparator

Interleukin (IL)-3, IL-6, granulocyte-macrophage colony stimulating factor (GM-CSF), erythropoietin (EPO), acid fibroblast growth factor (aFGF), and combinations with anti-IL-6, anti-IL-3, or anti-GM-CSF antibodies

Outcome

Megakaryocyte colony formation (CFU-MK)surrogate

Recombinant PDGF acts as a positive regulator for megakaryocytopoiesis in vitro, with its effects partially mediated by IL-6 and GM-CSF.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications for thrombocytopenia; leaves open PDGF's role in human megakaryopoiesis pending in vivo validation.

Cite This Study

Yang et al. (1995) studied this question.

synapsesocial.com/papers/6a953a97dd1b902261fa5ba4 https://doi.org/10.1111/j.1365-2141.1995.tb05291.x

View Full Paper

Ask AI

Bookmark

Recombinant PDGF enhances megakaryocytopoiesis in vitro

Structured PICO

Discussion

Implication

Cite This Study

Recombinant PDGF enhances megakaryocytopoiesis in vitro

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider