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April 1, 1989Journal of Medicinal ChemistryOpen Access

Identification of structural requirements for analogs of atrial natriuretic peptide (ANP) to discriminate between ANP receptor subtypes

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Population

Rabbit lung membranes

Comparison

Atrial natriuretic peptide and designed… vs ANP-(103-126)

Design

Preclinical

Authors

PBPhilippe R. BovySanofi (France)JOJoan M. O'NealMonsanto (United States)GOGillian M. OlinsWashington University in St. Louis

Discussion

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Implication

Provides selective non-GC ANP receptor probe in models; leaves open any human cardiovascular translation.

Structured PICO

P
Population
Rabbit lung membranes
I
Intervention
Atrial natriuretic peptide (ANP) and designed analogues (e.g., des-[Phe106, Gly107, Ala115, Gln116]ANP-(103-125)NH2 (4), des-[Cys105,121]ANP-(104-126) (5), and [Acm-Cys105]ANP-(105-114)NH2 (9))
C
Comparator
ANP-(103-126)
O
Outcome
Affinity and selective binding to guanylate cyclase coupled (CC) and non-cyclase coupled (NC) receptorssurrogate

A specific heptapeptide sequence from the cyclic core of ANP was identified as the minimal sequence for specific recognition of the non-guanylate cyclase coupled ANP receptor.

Cite This Study

Bovy et al. (1989) studied this question.

synapsesocial.com/papers/6a953b322fdd6c151ff22cd4https://doi.org/10.1021/jm00124a023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small atrial natriuretic peptide analogs: design, synthesis, and structural requirements for guanylate cyclase activation1992 · 21 citations
  2. 2Identification of renal natriuretic peptide receptor subpopulations by use of the non‐peptide antagonist, HS‐142‐11994 · 11 citations
  3. 3A Synthetic Linear Decapeptide Binds to the Atrial Natriuretic Peptide Receptors and Demonstrates Cyclase Activation and Vasorelaxant Activity1989 · 16 citations
  4. 4Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.1992 · 721 citations
  5. 5Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide1992 · 176 citations