Evolving strategies for renoprotection: non-diabetic chronic renal disease

This is the authors' abstract. We don't add key points for this paper.

Experimental and clinical studies over the past two decades have identified several interventions for slowing the progression of chronic renal disease towards end-stage renal failure. In this paper we review the experimental and clinical evidence in support of dietary protein restriction, angiotensin-converting enzyme inhibitor therapy, control of systemic hypertension, reduction of proteinuria, treatment of hyperlipidemia and smoking cessation. We also consider potential future renoprotective therapies. Finally we propose a comprehensive strategy for achieving maximal renoprotection with available interventions and monitoring.

Supports multimodal renoprotection in non-diabetic CKD; leaves open need for contemporary RCTs to refine targets.